Chapman displayed some discomfort after a groundout in the fifth inning, his first of the game against the Milwaukee Brewers.
Chapman slammed a ball to the dugout floor then left the field with a trainer.
The Reds announced that Chapman was removed for precautionary reasons, citing a tight hamstring.
Last spring on March 19, Chapman was hit in the head with a line drive from Salvador Perez of Kansas City.
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This one does not appear serious on the surface.