The Reds jumped on Cardinals starter John Lackey in the first inning and held on for its third straight win over their arch enemies 3-2.
Brandon Phillips and Joey Votto singled before Lackey could get loose. Todd Frazier hit into a double play and it looked like Lackey would escape but the red hot Jay Bruce doubled against the shift to score Phillips.
Reds' starter Anthony DeSclafani gave up a two-out single to Jason Heyward in the first but struck out four in two scoreless innings.
Randal Grichuk tripled over Billy Hamilton's head to start the third for the Cardinals. Matt Carpenter hit his 14th home run one out later. It was the first runs scored off Reds' pitching in 24 innings.
DeSclafani allowed one hit in the fourth, one in the fifth and two in the sixth but kept St. Louis off the scoreboard. He finished with six innings with two runs on seven hits and a career-high nine strikeouts.
The win evened DeSclafani's record at 7-7. He beat St. Louis in two straight starts.
"I had them guessing a lot more," DeSclafani said. "I try not to do anything different. I let Brayan (Pena) call the game. I was ready to make an in-game adjustment if I had to."
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Billy Hamilton nearly got to Grichuk's triple and did take an extra base hit away from Jason Heyward in the eighth inning.
"The ball took off," Hamilton said. "I've always played that way, 100 percent. I will watch the replays. Anything to take my mind off missing that bunt."
Burke Badenhop took over in the seventh. Since April, Badenhop has a 1.82 ERA in 33 appearances, turning in a scoreless inning..
Seth Maness took over for Lackey in the home seventh.
Skip Schumaker led off the inning with his league leading 15th pinch hit. Hamilton popped up an attempted sacrifice bunt.
J.J. Hoover worked a scoreless eighth to turn over the lead to Aroldis Chapman., looking for his 23rd save in 24 tries.
Chapman slammed the door with two strikeouts.
Chapman has saves in 56 straight opportunities at home.