Donald Lutz hit a three-run home run following Scott Rolens' RBI single to back up Homer Bailey's three scoreless innings.
Josh Judy pitched two scoreless innings. Andrew Brackman and Nick Christiani pitched one each. Pedro Villareal allowed one run in two innings.
Rolen is now 5-for-9 this spring and moving well in the field.
"I'm not worried about my health or seeing the ball," Rolen said. He fouled off two 3-2 pitches before he singled to score Joey Votto, who singled with two outs. Jay Bruce singled to right to set up Rolen's at bat.
"Scotty is almost there," Dusty Baker said. "Homer threw the ball great. All the guys threw the ball good. We had timely hits and Big Lutz's was the biggest."
The other Reds squad lost to San Francisco across town in Scottsdale.
Todd Frazier hit his second home run of the spring. Frazier, Juan Francisco and Danny Dorn drove in runs for the Reds.
Aroldis Chapman struck out two batters in two hitless innings. Danny Corcino allowed one run on four hits in two innings. Clayton Tanner pitched a scoreless frame. Sam LeCure had a rough two-inning stint allowing four runs on five hits, including a home run to Melky Cabrera.