Kenny Frease handled the first half but Tu Holloway took control in the second.
Holloway scored 20 points in the second half to lead Xavier to its 37th straight conference home win, an A-10 record. Frease scored an even dozen in the first half and finished with 12. Jamel McLean scored 11 and Mark Lyons contributed 15.
Brian Conklin led the Billikens with 24 and Rob Loe scored 18. Loe had just three at halftime but brought Saint Louis back from a seven point deficit. Loe hit two 3-pointers and Conklin had three quick field goals to give Saint Louis a four point lead until Holloway hit a key basket at the 14 minute mark to tie the game.
Xavier built an eight point lead from there to take control.
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