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Mike Leake homered for the second time this season and fourth time in his career but gave up a big home run to Mike Napli with a runner on to give back the lead, the home run staked him to.
The 5-4 decision was the fourth one-run loss to Boston this season, two in Boston in May and the last two nights in Cincinnati. It dropped the Reds' record to 60-60.
Yoenis Cespedes had two singles and two RBI before he left the game with a contusion on his right hand. Cepedes who homered to put the Red Sox in the lead on Wednesday, was on base with a game-tying single when Napoli connected on his 15th of the season.
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Brock Holt singled off Leake and took second when a pitch got away from Reds' catcher Devin Mesoraco. Daniel Nava singled to plate Holt and went to second on the throw home. Nava took third on a slow roller to short and scored on a fielder's choice when Todd Frazier's throw to the plate on Napoli's ground ball was late.
The Reds dealt themselves back into the game on a single by Kristopher Negron, a ground-rule double by Frazier. Devin Mesoraco's fly to deep center brought Negron home.
Skip Schumaker and Leake both hit their second home run of the season off Ranaudo and took a brief lead.
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Frazier's sacrifice fly followed Negron's first career triple to make it a one-run game.
Aroldis Chapman struck out the side in the ninth, extending his streak to 49 appearances with at least one strikeout. He ha struck out the side 10 times this season.
Former Cardianal closer Edward Mujica survived two singles to open the ninth to earn his third save.
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