Cincinnati scored two touchdowns in the third quarter to take command of the game against the Purdue Boilermakers.
Adrian Witty returned an interception 41 yards for another score.
Tony Millano is 4-for-4 on extra-point attempts.
The Bearcats have 293 yards of total offense to Purdue's 111 yards.
The Bearcats take a 28-7 lead into the fourth quarter.