Last year's top pick in the draft, Paul Skenes, won his 10th game for the Pittsburgh Pirates with five scoreless innings in a 2-0 triumph.
The loss was the 81st for the Reds, the best they can do is reach the .500 mark if it sweeps the last five games in Cleveland and Chicago.
Hunter Greene made his first start since August 13th when a bruised elbow forced him to the injured list.
He was under "controlled" conditions because he missed enough time the Reds had to stretch him out slowly.
The only blemish on his three innings was the 21st home run of the season by Oneil Cruz.
Nick Yorke led off the fifth inning with his first Major League home run off Fernando Cruz.
Skenes pitched five innings, allowign two hits, both singles. He struck out nine batters. In his three starts against the Reds, Skenes has allowed one run in 17 innings. He has now allowed three runs or fewer in 21 of his 23 starts. Skenes dropped his ERA under two at 1.99 for the season.
The Reds didn't get a runner to second base all day.
"He throws 100 mph. He has a sinker, a right on right change. He has a lot of pitches that he can throw where he wants, when he wants."
"He (Skenes) dominated really. He had a really good change up. It was kind of his growth since the last time we faced," Reds' manager David Bell said. "That was the difference maker for him today."
Former Red Aroldis Chapman earned his 11th save of the season by striking out two. He now has 77 saves at Great American Ball Park.
It was the final home game for the Reds, who drew 2,024,186 with an average of 24,990.